Speed dating 50 Krupina Slovensko
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Speed Dating for 35-49 & 50-65
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Median PWVao values and age of the Central European population according to Reference [ 33 ]. In this study, the aorta elasticity was determined through measurements of PWVao and the arterial age of respondents. The measured results were compared with average values established for the Central European population.
Average arterial age does not correspond to the actual age of an individual but it reflects the status age of arteries. The arterial age can be higher or lower than the actual age of the respondent. The more flexible the wall of the arteries, the lower the pulse wave velocity, so the aorta is healthier and its age is lower than the physical, i.
Drinking waters analyzed in this study came directly from the water resources that supply residents in the Krupina district.
There will be an opportunity to mix with the other age group during the break. Tvárou v tvár stretnete skutočných ľudí, z mäsa a kostí, nie tiene z virtuálnych zoznamiek a mäsových socialnych sietí. ASE's Speed Dating Year Old's La Zeppa Kitchen and Bar , Freemans Bay, Auckland Thu 11 Mar pm. Within 50 miles contains large variations in elevation 6, feet. Nič nenahradí osobnú komunkáciu z očí do očí. We find it necessary to verify our results in other countries around the world.
The source of drinking water was exclusively groundwater, which was pumped from wells and captured springs. The analyses were carried out in accordance with the Slovak drinking water standard Government Regulation No. The total dissolved solids TDS of drinking water were determined using the gravimetric method on water samples dried at °C [ 35 ]. The water hardness was expressed as the sum of the molar concentrations of dissolved Ca and Mg. Calcium and Mg were measured using inductively coupled plasma-optical emission spectrometry ICP-OES; Liberty , Varian, Palo Alto, CA, USA.
The results of the measurements were expressed using average, median, standard deviation, and range minimum—maximum. An independent sample t test and Mann—Whitney test were used to evaluate statistical differences between groups of populations living in the hard water and soft water areas. The z -test and the Monte Carlo method were used to test differences in the proportions of males and females, and smokers and non-smokers among populations living in the hard drinking water and soft drinking water areas.
Multivariate analysis of variance MANOVA was also performed to test whether other factors sex, age, smoking, and body mass index affected the measured variables, especially the values of PWVao and the difference between arterial and actual age. Statistical processing of the results was done using XLSTAT software Addinsoft Inc, Long Island City, NY, USA. The results of arterial stiffness measurements for the first, second, and both phases are summarized in Table 4.
Differences in PWVao values and arterial age of respondents as a function of water hardness are presented in the form of scatter plots in Figure 4. In addition, Figure 5 illustrates graphically the difference between the arterial and actual age of females and males for both measurement phases. The greater the difference, the worse the arterial health. Scatter plot showing aortic pulse wave velocity PWVao values and arterial age of residents living in areas with different contents of Ca and Mg in drinking water. Horizontal continuous lines are the median values.
White and yellow circles represent the individual PWVao values of the residents from hard and soft drinking water areas, respectively, while the white and yellow inverted triangles are the calculated arterial ages of the residents from hard and soft drinking water areas, respectively. Differences between the arterial and actual age of residents living in areas with soft and hard drinking water. Common statistical parameters of the measured characteristics of respondents in the 1 st , 2 nd and both research phases.
To investigate the effects of other possible factors on arterial health, multivariate analysis of variance was used. The results of this analysis indicated that risk factors, such as smoking and BMI, did not affect PWVao values, arterial age, and the difference between arterial and actual age in any of the two areas studied Table 5. The influence of sex was not confirmed, and only age affected these variables.
However, the average actual age of the population from the hard water area did not differ significantly from the age of the population from the soft water area Table 2 and Table 4. Results of multivariate variance analysis MANOVA; Lawley—Hotelling trace test. These differences have been documented in both phases of the research. The more favorable artery status was observed in the areas supplied with hard drinking water compared to areas supplied with soft water.
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Two residents had an average result and the arterial age of 10 residents was better than their actual age. Compared to the average values for the Central European population, the respondents had an arterial age better lower by approximately 3. Five residents had average results and 6 had a better arterial age than their actual age. Respondents had an average arterial age that was worse by 1.
Four residents had average results and better arterial age was documented in 27 residents. On average, the residents living in areas with harder drinking water had an arterial age approximately 3. One resident had an average result and 20 residents presented a better arterial age than their respective actual age. The residents had on average an arterial age that was 0. The values of PWVao were also generally higher compared to the PWVao values obtained from measurements of residents from the control group areas with the harder drinking water.
These findings confirmed the results from the first phase of measurements. This was also reflected by higher PWVao levels, increased number of pathological conditions, and consequently, by a higher arterial age of residents compared to their actual age. The results, including all respondents who participated in the measurement of arterial stiffness, indicated the potential impact of soft drinking water on the impaired status of arteries of the population.
This was particularly due to a greater number of extreme PWVao values, and subsequently, a significantly higher arterial age of residents living in soft drinking water area Figure 4 and Table 4 , and a higher deviation from the values established for the Central European population.
In addition, as can be seen from Table 4 , it was found that the difference between the arterial and actual age of residents supplied with soft drinking water was on average including both the first and second phases of measurements 4. Small differences between the arterial and actual age were also observed according to sex, i.
In the case of both males as well as females, a better status of arteries in inhabitants from areas supplied with hard drinking water was observed. However, no statistically significant difference in this parameter was confirmed in males Figure 5 , which might be related to the small number of males included in the study. These results can hardly be confronted with other works because, to our best knowledge, there is no literature documenting the relationship between arterial stiffness and water hardness.
However, it should be noted that medical studies clearly show the protective role of Mg and Ca for arteries [ 36 , 37 , 38 ]. Magnesium deficiency has been shown to have a detrimental effect on arterial elasticity [ 39 , 40 ], and it is well known that the state of arteries has a direct relationship to the development of cardio-vascular diseases [ 27 ].
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Several works from other countries around the world have shown a positive, i. In particular, it is possible to state the work of Yousefi et al. They have shown that the prevalence of hypertension is significantly higher in areas with low water hardness than in those with higher water hardness. However, it should be noted that there are also studies that have shown no relationship between water hardness and cardiovascular diseases [ 45 , 46 ]. This study showed higher arterial stiffness lower flexibility of arteries and higher arterial age in residents who are supplied with soft drinking water with Ca and Mg deficiency compared to the group of residents with a hard drinking water supply.
harder water was almost 5. Averaging all measured data, the difference was higher by 4.
If the median values are used for comparison, the difference reached up to 9 years. The results of the two-phased arterial stiffness measurements support the assumption of a potentially negative impact of the unfavourable geological environment, reflected in the low mineralization and hardness of drinking water, as a significant environmental factor on the health status of the population living in the Krupina district. We find it necessary to verify our results in other countries around the world.
If our findings are confirmed in other countries, it will be another reason to include Ca and Mg among regulated elements in the WHO drinking water standard. The authors would like to thank all the volunteers who participated in the measurements of arterial stiffness. We would like to acknowledge the valuable comments of three anonymous reviewers that helped us to improve the manuscript. designed the study and wrote the manuscript; V. searched the relevant literature and prepared the figures; K. participated in the interpretation of results; I.
performed measurements of PWVao values and prepared the questionnaire for respondents included in the study; E. wrote and edited the manuscript, performed statistics, and searched the literature; B. helped in performing advanced statistics and revision of the manuscript. All the authors have read and approved the final manuscript before its submission to the journal office. The authors declare no conflict of interest.
The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.